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Professor Jan Manuel Rodriguez Parkitna, dr hab.
Professor Jan Manuel Rodriguez Parkitna, dr hab.
+48 12 6623316
room 210 Achievements
- Publications
Loss of NMDA receptors in dopamine neurons leads to the development of affective disorder-like symptoms in mice.
Autorzy: Jastrzębska K, Walczak M, Cieślak PE, Szumiec Ł, Turbasa M, Engblom D, Błasiak T, Parkitna JR
DOI: 10.1038/srep37171
Molecular profile of dissociative drug ketamine in relation to its rapid antidepressant action.
Autorzy: Ficek J, Zygmunt M, Piechota M, Hoinkis D, Rodriguez Parkitna J, Przewlocki R, Korostynski M
DOI: 10.1186/s12864-016-2713-3
Effects of glycogen synthase kinase 3beta and cyclin-dependent kinase 5 inhibitors on morphine-induced analgesia and tolerance in rats.
Autorzy: Parkitna JR, Obara I, Wawrzczak-Bargiela A, Makuch W, Przewlocka B, Przewlocki R
DOI: 10.1124/jpet.106.107581
Nonmotor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson’s disease
Autorzy: Anna Radlicka, Judyta Jabłońska, Michał Lenarczyk, Łukasz Szumiec, Zofia Harda, Monika Bagińska, Joanna Pera, Grzegorz Kreiner, Daniel Wójcik, Jan Rodriguez Parkitna
DOI: 10.1101/2023.01.23.525182
Establishment of a social conditioned place preference paradigm for the study of social reward in female mice
Autorzy: Zofia Harda, Magdalena Chrószcz, Klaudia Misiołek, Marta Klimczak, Łukasz Szumiec, Maria Kaczmarczyk-Jarosz, Jan Rodriguez Parkitna
DOI: 10.1101/2022.03.31.486566
Time elapsed between choices in a probabilistic task correlates with repeating the same decision
Autorzy: Judyta Jabłońska, Łukasz Szumiec, Piotr Zieliński, Jan Rodriguez Parkitna
DOI: 10.1111/ejn.15144
Prospects for personalization of depression treatment with genome sequencing
Autorzy: Malgorzata Borczyk, Marcin Piechota, Jan Rodriguez Parkitna, Michal Korostynski
DOI: 10.1111/bph.15470
Effects of L-DOPA on gene expression in the frontal cortex of rats with unilateral lesion of midbrain dopaminergic neurons
Autorzy: Anna Radlicka, Kinga Kamińska, Malgorzata Borczyk, Marcin Piechota, Michał Korostyński, Joanna Pera, Elżbieta Lorenc-Koci, Jan Rodriguez Parkitna
DOI: 10.1101/2020.04.28.063347
MicroRNAs are indispensable for the proliferation and differentiation of adult neural progenitor cells in mice
Autorzy: Yang Xu, Karolina Hajdukiewicz, Anshul Tiwari, Joanna Przybyś, Jan Rodriguez Parkitna, Martin Novak, Ilya A. Vinnikov, Günther Schütz, Witold Konopka
DOI: 10.1016/j.bbrc.2020.06.143
Prosocial behavior, social reward and affective state discrimination in adult male and female mice
Autorzy: Klaudia Misiołek, Marta Klimczak, Magdalena Chrószcz, Łukasz Szumiec, Anna Bryksa, Karolina Przyborowicz, Jan Rodriguez Parkitna, Zofia Harda
DOI: 10.1101/2022.08.19.504492
Decoding the transcriptional programs activated by psychotropic drugs in the brain
Autorzy: Magdalena Zygmunt, Marcin Piechota, Jan Rodriguez Parkitna, Michał Korostyński
DOI: 10.1111/gbb.12511
Antagonism of μ-opioid receptors reduces sensation seeking-like behavior in mice
Autorzy: Magdalena Sikora, Urszula Skupio, Kamila Jastrzebska, Jan Rodriguez Parkitna, Ryszard Przewlocki
DOI: 10.1016/j.bbr.2018.11.039
Time elapsed between choices in a probabilistic task correlates with repeating the same decision
Autorzy: Judyta Jabłońska, Łukasz Szumiec, Piotr Zieliński, Jan Rodriguez Parkitna
DOI: 10.1101/643965
Effects of L-DOPA on Gene Expression in the Frontal Cortex of Rats with Unilateral Lesions of Midbrain Dopaminergic Neurons
Autorzy: Anna Radlicka, Kinga Kamińska, Malgorzata Borczyk, Marcin Piechota, Michał Korostyński, Joanna Pera, Elżbieta Lorenc-Koci, Jan Rodriguez Parkitna
DOI: 10.1523/ENEURO.0234-20.2020
Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity.
Autorzy: Harda Z, Spyrka J, Jastrzębska K, Szumiec Ł, Bryksa A, Klimczak M, Polaszek M, Gołda S, Zajdel J, Misiołek K, Błasiak A, Rodriguez Parkitna J
DOI: 10.1016/j.neuropharm.2020.108307
Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity
Autorzy: Harda Z, Spyrka J, Jastrzębska K, Szumiec Ł, Bryksa A, Klimczak M, Polaszek M, Gołda S, Zajdel J, Błasiak A, Parkitna JR
DOI: 10.1101/2020.03.18.996454
Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats.
Autorzy: Noworyta-Sokolowska K, Kozub A, Jablonska J, Rodriguez Parkitna J, Drozd R, Rygula R
DOI: 10.1007/s00213-019-05333-w
The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons.
Autorzy: Ruud J, Alber J, Tokarska A, Engström Ruud L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cieślak PE, Szumiec Ł, Hess ME, Brönneke HS, Krüger M, Brüning JC
DOI: 10.1016/j.celrep.2019.05.037
Ablation of NMDA receptors in dopamine neurons disrupts attribution of incentive salience to reward-paired stimuli.
Autorzy: Cieślak PE, Rodriguez Parkitna J
DOI: 10.1016/j.bbr.2019.01.037
Ablation of NMDA receptors in dopamine neurons disrupts attribution of incentive salience to reward-paired stimuli
Autorzy: Cieślak PE, Parkitna JR
DOI: 10.1101/439745
Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs.
Autorzy: Zygmunt M, Hoinkis D, Hajto J, Piechota M, Skupień-Rabian B, Jankowska U, Kędracka-Krok S, Rodriguez Parkitna J, Korostyński M
DOI: 10.1186/s12868-018-0458-4
Selective Effects of the Loss of NMDA or mGluR5 Receptors in the Reward System on Adaptive Decision-Making.
Autorzy: Cieślak PE, Ahn WY, Bogacz R, Rodriguez Parkitna J
DOI: 10.1523/eneuro.0331-18.2018
Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABAA receptors on dopamine neurons in mice.
Autorzy: Stojakovic A, Walczak M, Cieślak PE, Trenk A, Sköld J, Zajdel J, Mirrasekhian E, Karlsson C, Thorsell A, Heilig M, Parkitna JR, Błasiak T, Engblom D
DOI: 10.1038/s41386-018-0022-z
Cognitive Judgment Bias Interacts with Risk Based Decision Making and Sensitivity to Dopaminergic Challenge in Male Rats.
Autorzy: Drozd R, Cieslak PE, Rychlik M, Rodriguez Parkitna J, Rygula R
DOI: 10.3389/fnbeh.2016.00163
NMDA Receptors on Dopaminoceptive Neurons Are Essential for Drug-Induced Conditioned Place Preference.
Autorzy: Sikora M, Tokarski K, Bobula B, Zajdel J, Jastrzębska K, Cieślak PE, Zygmunt M, Sowa J, Smutek M, Kamińska K, Gołembiowska K, Engblom D, Hess G, Rodriguez Parkitna J
DOI: 10.1523/eneuro.0084-15.2016
Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.
Autorzy: Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Wilhelms DB, Lazarus M, Löfberg A, Jaarola M, Kugelberg UÖ, Billiar TR, Hackam DJ, Sodhi CP, Engblom D
DOI: 10.1172/jci83844
Corrigendum: CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects.
Autorzy: Bilbao A, Rieker C, Cannella N, Parlato R, Golda S, Piechota M, Korostynski M, Engblom D, Przewlocki R, Schütz G, Spanagel R, Rodriguez Parkitna J
DOI: 10.3389/fnbeh.2014.00239
CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects.
Autorzy: Bilbao A, Rieker C, Cannella N, Parlato R, Golda S, Piechota M, Korostynski M, Engblom D, Przewlocki R, Schütz G, Spanagel R, Parkitna JR
DOI: 10.3389/fnbeh.2014.00212
A model of alcohol drinking under an intermittent access schedule using group-housed mice.
Autorzy: Smutek M, Turbasa M, Sikora M, Piechota M, Zajdel J, Przewlocki R, Parkitna JR
DOI: 10.1371/journal.pone.0096787
Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons.
Autorzy: Kiryk A, Sowodniok K, Kreiner G, Rodriguez-Parkitna J, Sönmez A, Górkiewicz T, Bierhoff H, Wawrzyniak M, Janusz AK, Liss B, Konopka W, Schütz G, Parlato R
DOI: 10.3389/fncel.2013.00207
Addictive drugs and plasticity of glutamatergic synapses on dopaminergic neurons: what have we learned from genetic mouse models?
Autorzy: Rodriguez Parkitna J, Engblom D
DOI: 10.3389/fnmol.2012.00089
Novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice are controlled by metabotropic glutamate receptor 5 on neurons expressing dopamine d1 receptors.
Autorzy: Parkitna JR, Sikora M, Gołda S, Gołembiowska K, Bystrowska B, Engblom D, Bilbao A, Przewlocki R
DOI: 10.1016/j.biopsych.2012.07.019
Ablation of serum response factor in dopaminergic neurons exacerbates susceptibility towards MPTP-induced oxidative stress.
Autorzy: Rieker C, Schober A, Bilbao A, Schütz G, Parkitna JR
DOI: 10.1111/j.1460-9568.2012.08003.x
Glutamate input to noradrenergic neurons plays an essential role in the development of morphine dependence and psychomotor sensitization.
Autorzy: Parkitna JR, Solecki W, Gołembiowska K, Tokarski K, Kubik J, Gołda S, Novak M, Parlato R, Hess G, Sprengel R, Przewłocki R
DOI: 10.1017/s1461145711001568
Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages.
Autorzy: Kleiman A, Hübner S, Rodriguez Parkitna JM, Neumann A, Hofer S, Weigand MA, Bauer M, Schmid W, Schütz G, Libert C, Reichardt HM, Tuckermann JP
DOI: 10.1096/fj.11-192112
Glucocorticoid activity during lung maturation is essential in mesenchymal and less in alveolar epithelial cells.
Autorzy: Habermehl D, Parkitna JR, Kaden S, Brügger B, Wieland F, Gröne HJ, Schütz G
DOI: 10.1210/me.2009-0380
MicroRNA loss enhances learning and memory in mice.
Autorzy: Konopka W, Kiryk A, Novak M, Herwerth M, Parkitna JR, Wawrzyniak M, Kowarsch A, Michaluk P, Dzwonek J, Arnsperger T, Wilczynski G, Merkenschlager M, Schütz G
DOI: 10.1523/jneurosci.3030-10.2010
Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons.
Autorzy: Novak M, Halbout B, O'Connor EC, Rodriguez Parkitna J, Su T, Chai M, Crombag HS, Bilbao A, Spanagel R, Stephens DN, Schütz G, Engblom D
DOI: 10.1523/jneurosci.2550-10.2010
Effects of the cell type-specific ablation of the cAMP-responsive transcription factor in noradrenergic neurons on locus coeruleus firing and withdrawal behavior after chronic exposure to morphine.
Autorzy: Parlato R, Cruz H, Otto C, Murtra P, Parkitna JR, Martin M, Bura SA, Begus-Nahrmann Y, von Bohlen und Halbach O, von Bohlen und Halbach O, Lüscher C
DOI: 10.1111/j.1471-4159.2010.06709.x
Loss of the serum response factor in the dopamine system leads to hyperactivity.
Autorzy: Parkitna JR, Bilbao A, Rieker C, Engblom D, Piechota M, Nordheim A, Spanagel R, Schütz G
DOI: 10.1096/fj.09-151423
Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc.
Autorzy: Mameli M, Halbout B, Creton C, Engblom D, Parkitna JR, Spanagel R, Lüscher C
DOI: 10.1038/nn.2367
Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain.
Autorzy: Obara I, Parkitna JR, Korostynski M, Makuch W, Kaminska D, Przewlocka B, Przewlocki R
DOI: 10.1016/j.pain.2008.12.006
Generation of Cre recombinase-expressing transgenic mice using bacterial artificial chromosomes.
Autorzy: Parkitna JR, Engblom D, Schütz G
DOI: 10.1007/978-1-59745-471-1_17
Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine.
Autorzy: Bilbao A, Parkitna JR, Engblom D, Perreau-Lenz S, Sanchis-Segura C, Schneider M, Konopka W, Westphal M, Breen G, Desrivieres S, Klugmann M, Spanagel R
DOI: 10.1073/pnas.0803959105
Glutamate receptors on dopamine neurons control the persistence of cocaine seeking.
Autorzy: Engblom D, Bilbao A, Sanchis-Segura C, Dahan L, Perreau-Lenz S, Balland B, Parkitna JR, Luján R, Halbout B, Mameli M, Parlato R, Sprengel R, Spanagel R
DOI: 10.1016/j.neuron.2008.07.010
CREB has a context-dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis.
Autorzy: Lemberger T, Parkitna JR, Chai M, Schütz G, Engblom D
DOI: 10.1096/fj.08-107888
Cloning and sequence analysis of Galleria mellonella juvenile hormone binding protein--a search for ancestors and relatives.
Autorzy: Rodriguez Parkitna JM, Ozyhar A, Wiśniewski JR, Kochman M
DOI: 10.1515/bc.2002.153
Temperature-sensitive ovarian carcinoma cell line (OvBH-1).
Autorzy: Bar JK, Harlozinska A, Kartarius S, Montenarh M, Wyrodek E, Parkitna JM, Kochman M, Ozyhar A
DOI: 10.1111/j.1349-7006.2002.tb02473.x
Juvenile hormone binding protein and transferrin from Galleria mellonella share a similar structural motif.
Autorzy: Krzyzanowska D, Ozyhar A, Lalik A, Parkitna JM, Szkudlarek J, Waśniowska K, Lisowska E, Kochman M
DOI: 10.1515/bc.2001.129
Dopamine Receptor-Expressing Neurons Are Differently Distributed throughout Layers of the Motor Cortex to Control Dexterity
Autorzy: Przemyslaw E. Cieslak, Sylwia Drabik, Anna Gugula, Aleksandra Trenk, Martyna Gorkowska, Kinga Przybylska, Lukasz Szumiec, Grzegorz Kreiner, Jan Rodriguez Parkitna, Anna Blasiak
DOI: 10.1523/ENEURO.0490-23.2023
Immunoaffinity purification of juvenile hormone-binding protein from Galleria mellonella hemolymph.
Autorzy: Wieczorek E, Parkitna JM, Szkudlarek J, Ozyhar A, Kochman M
DOI: