Jan Manuel Rodriguez Parkitna, Pracownik Instytut Farmakologii PAN

prof. dr hab. Jan Manuel Rodriguez Parkitna

Zastępca Dyrektora ds. Naukowych

+48 12 6623316

[email protected]

Dokonania naukowe

Publikacje

DOI: 10.1038/srep37171

DOI: 10.1186/s12864-016-2713-3

DOI: 10.1124/jpet.106.107581

DOI: 10.1101/2023.01.23.525182

DOI: 10.1101/2022.03.31.486566

DOI: 10.1111/ejn.15144

DOI: 10.1111/bph.15470

DOI: 10.1101/2020.04.28.063347

DOI: 10.1016/j.bbrc.2020.06.143

DOI: 10.1101/2022.08.19.504492

DOI: 10.1111/gbb.12511

DOI: 10.1016/j.bbr.2018.11.039

DOI: 10.1101/643965

DOI: 10.1523/ENEURO.0234-20.2020

DOI: 10.1016/j.neuropharm.2020.108307

DOI: 10.1101/2020.03.18.996454

DOI: 10.1007/s00213-019-05333-w

DOI: 10.1016/j.celrep.2019.05.037

DOI: 10.1016/j.bbr.2019.01.037

DOI: 10.1101/439745

DOI: 10.1186/s12868-018-0458-4

DOI: 10.1523/eneuro.0331-18.2018

DOI: 10.1038/s41386-018-0022-z

DOI: 10.3389/fnbeh.2016.00163

DOI: 10.1523/eneuro.0084-15.2016

DOI: 10.1172/jci83844

DOI: 10.3389/fnbeh.2014.00239

DOI: 10.3389/fnbeh.2014.00212

DOI: 10.1371/journal.pone.0096787

DOI: 10.3389/fncel.2013.00207

DOI: 10.3389/fnmol.2012.00089

DOI: 10.1016/j.biopsych.2012.07.019

DOI: 10.1111/j.1460-9568.2012.08003.x

DOI: 10.1017/s1461145711001568

DOI: 10.1096/fj.11-192112

DOI: 10.1210/me.2009-0380

DOI: 10.1523/jneurosci.3030-10.2010

DOI: 10.1523/jneurosci.2550-10.2010

DOI: 10.1111/j.1471-4159.2010.06709.x

DOI: 10.1096/fj.09-151423

DOI: 10.1038/nn.2367

DOI: 10.1016/j.pain.2008.12.006

DOI: 10.1007/978-1-59745-471-1_17

DOI: 10.1073/pnas.0803959105

DOI: 10.1016/j.neuron.2008.07.010

DOI: 10.1096/fj.08-107888

DOI: 10.1515/bc.2002.153

DOI: 10.1111/j.1349-7006.2002.tb02473.x

DOI: 10.1515/bc.2001.129

DOI: 10.1523/ENEURO.0490-23.2023

prof. dr hab. Jan Manuel Rodriguez Parkitna

Dokonania naukowe

Loss of NMDA receptors in dopamine neurons leads to the development of affective disorder-like symptoms in mice.

Autorzy: Jastrzębska K, Walczak M, Cieślak PE, Szumiec Ł, Turbasa M, Engblom D, Błasiak T, Parkitna JR

Molecular profile of dissociative drug ketamine in relation to its rapid antidepressant action.

Autorzy: Ficek J, Zygmunt M, Piechota M, Hoinkis D, Rodriguez Parkitna J, Przewlocki R, Korostynski M

Effects of glycogen synthase kinase 3beta and cyclin-dependent kinase 5 inhibitors on morphine-induced analgesia and tolerance in rats.

Autorzy: Parkitna JR, Obara I, Wawrzczak-Bargiela A, Makuch W, Przewlocka B, Przewlocki R

Nonmotor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson’s disease

Autorzy: Anna Radlicka, Judyta Jabłońska, Michał Lenarczyk, Łukasz Szumiec, Zofia Harda, Monika Bagińska, Joanna Pera, Grzegorz Kreiner, Daniel Wójcik, Jan Rodriguez Parkitna

Establishment of a social conditioned place preference paradigm for the study of social reward in female mice

Autorzy: Zofia Harda, Magdalena Chrószcz, Klaudia Misiołek, Marta Klimczak, Łukasz Szumiec, Maria Kaczmarczyk-Jarosz, Jan Rodriguez Parkitna

Time elapsed between choices in a probabilistic task correlates with repeating the same decision

Autorzy: Judyta Jabłońska, Łukasz Szumiec, Piotr Zieliński, Jan Rodriguez Parkitna

Prospects for personalization of depression treatment with genome sequencing

Autorzy: Malgorzata Borczyk, Marcin Piechota, Jan Rodriguez Parkitna, Michal Korostynski

Effects of L-DOPA on gene expression in the frontal cortex of rats with unilateral lesion of midbrain dopaminergic neurons

Autorzy: Anna Radlicka, Kinga Kamińska, Malgorzata Borczyk, Marcin Piechota, Michał Korostyński, Joanna Pera, Elżbieta Lorenc-Koci, Jan Rodriguez Parkitna

MicroRNAs are indispensable for the proliferation and differentiation of adult neural progenitor cells in mice

Autorzy: Yang Xu, Karolina Hajdukiewicz, Anshul Tiwari, Joanna Przybyś, Jan Rodriguez Parkitna, Martin Novak, Ilya A. Vinnikov, Günther Schütz, Witold Konopka

Prosocial behavior, social reward and affective state discrimination in adult male and female mice

Autorzy: Klaudia Misiołek, Marta Klimczak, Magdalena Chrószcz, Łukasz Szumiec, Anna Bryksa, Karolina Przyborowicz, Jan Rodriguez Parkitna, Zofia Harda

Decoding the transcriptional programs activated by psychotropic drugs in the brain

Autorzy: Magdalena Zygmunt, Marcin Piechota, Jan Rodriguez Parkitna, Michał Korostyński

Antagonism of μ-opioid receptors reduces sensation seeking-like behavior in mice

Autorzy: Magdalena Sikora, Urszula Skupio, Kamila Jastrzebska, Jan Rodriguez Parkitna, Ryszard Przewlocki

Time elapsed between choices in a probabilistic task correlates with repeating the same decision

Autorzy: Judyta Jabłońska, Łukasz Szumiec, Piotr Zieliński, Jan Rodriguez Parkitna

Effects of L-DOPA on Gene Expression in the Frontal Cortex of Rats with Unilateral Lesions of Midbrain Dopaminergic Neurons

Autorzy: Anna Radlicka, Kinga Kamińska, Malgorzata Borczyk, Marcin Piechota, Michał Korostyński, Joanna Pera, Elżbieta Lorenc-Koci, Jan Rodriguez Parkitna

Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity.

Autorzy: Harda Z, Spyrka J, Jastrzębska K, Szumiec Ł, Bryksa A, Klimczak M, Polaszek M, Gołda S, Zajdel J, Misiołek K, Błasiak A, Rodriguez Parkitna J

Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity

Autorzy: Harda Z, Spyrka J, Jastrzębska K, Szumiec Ł, Bryksa A, Klimczak M, Polaszek M, Gołda S, Zajdel J, Błasiak A, Parkitna JR

Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats.

Autorzy: Noworyta-Sokolowska K, Kozub A, Jablonska J, Rodriguez Parkitna J, Drozd R, Rygula R

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons.

Autorzy: Ruud J, Alber J, Tokarska A, Engström Ruud L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cieślak PE, Szumiec Ł, Hess ME, Brönneke HS, Krüger M, Brüning JC

Ablation of NMDA receptors in dopamine neurons disrupts attribution of incentive salience to reward-paired stimuli.

Autorzy: Cieślak PE, Rodriguez Parkitna J

Ablation of NMDA receptors in dopamine neurons disrupts attribution of incentive salience to reward-paired stimuli

Autorzy: Cieślak PE, Parkitna JR

Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs.

Autorzy: Zygmunt M, Hoinkis D, Hajto J, Piechota M, Skupień-Rabian B, Jankowska U, Kędracka-Krok S, Rodriguez Parkitna J, Korostyński M

Selective Effects of the Loss of NMDA or mGluR5 Receptors in the Reward System on Adaptive Decision-Making.

Autorzy: Cieślak PE, Ahn WY, Bogacz R, Rodriguez Parkitna J

Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABAA receptors on dopamine neurons in mice.

Autorzy: Stojakovic A, Walczak M, Cieślak PE, Trenk A, Sköld J, Zajdel J, Mirrasekhian E, Karlsson C, Thorsell A, Heilig M, Parkitna JR, Błasiak T, Engblom D

Cognitive Judgment Bias Interacts with Risk Based Decision Making and Sensitivity to Dopaminergic Challenge in Male Rats.

Autorzy: Drozd R, Cieslak PE, Rychlik M, Rodriguez Parkitna J, Rygula R

NMDA Receptors on Dopaminoceptive Neurons Are Essential for Drug-Induced Conditioned Place Preference.

Autorzy: Sikora M, Tokarski K, Bobula B, Zajdel J, Jastrzębska K, Cieślak PE, Zygmunt M, Sowa J, Smutek M, Kamińska K, Gołembiowska K, Engblom D, Hess G, Rodriguez Parkitna J

Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.

Autorzy: Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Wilhelms DB, Lazarus M, Löfberg A, Jaarola M, Kugelberg UÖ, Billiar TR, Hackam DJ, Sodhi CP, Engblom D

Corrigendum: CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects.

Autorzy: Bilbao A, Rieker C, Cannella N, Parlato R, Golda S, Piechota M, Korostynski M, Engblom D, Przewlocki R, Schütz G, Spanagel R, Rodriguez Parkitna J

CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects.

Autorzy: Bilbao A, Rieker C, Cannella N, Parlato R, Golda S, Piechota M, Korostynski M, Engblom D, Przewlocki R, Schütz G, Spanagel R, Parkitna JR

A model of alcohol drinking under an intermittent access schedule using group-housed mice.

Autorzy: Smutek M, Turbasa M, Sikora M, Piechota M, Zajdel J, Przewlocki R, Parkitna JR

Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons.

Autorzy: Kiryk A, Sowodniok K, Kreiner G, Rodriguez-Parkitna J, Sönmez A, Górkiewicz T, Bierhoff H, Wawrzyniak M, Janusz AK, Liss B, Konopka W, Schütz G, Parlato R

Addictive drugs and plasticity of glutamatergic synapses on dopaminergic neurons: what have we learned from genetic mouse models?

Autorzy: Rodriguez Parkitna J, Engblom D

Novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice are controlled by metabotropic glutamate receptor 5 on neurons expressing dopamine d1 receptors.

Autorzy: Parkitna JR, Sikora M, Gołda S, Gołembiowska K, Bystrowska B, Engblom D, Bilbao A, Przewlocki R

Ablation of serum response factor in dopaminergic neurons exacerbates susceptibility towards MPTP-induced oxidative stress.

Autorzy: Rieker C, Schober A, Bilbao A, Schütz G, Parkitna JR

Glutamate input to noradrenergic neurons plays an essential role in the development of morphine dependence and psychomotor sensitization.

Autorzy: Parkitna JR, Solecki W, Gołembiowska K, Tokarski K, Kubik J, Gołda S, Novak M, Parlato R, Hess G, Sprengel R, Przewłocki R

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages.

Autorzy: Kleiman A, Hübner S, Rodriguez Parkitna JM, Neumann A, Hofer S, Weigand MA, Bauer M, Schmid W, Schütz G, Libert C, Reichardt HM, Tuckermann JP

Glucocorticoid activity during lung maturation is essential in mesenchymal and less in alveolar epithelial cells.

Autorzy: Habermehl D, Parkitna JR, Kaden S, Brügger B, Wieland F, Gröne HJ, Schütz G

MicroRNA loss enhances learning and memory in mice.

Autorzy: Konopka W, Kiryk A, Novak M, Herwerth M, Parkitna JR, Wawrzyniak M, Kowarsch A, Michaluk P, Dzwonek J, Arnsperger T, Wilczynski G, Merkenschlager M, Schütz G

Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons.

Autorzy: Novak M, Halbout B, O'Connor EC, Rodriguez Parkitna J, Su T, Chai M, Crombag HS, Bilbao A, Spanagel R, Stephens DN, Schütz G, Engblom D

Effects of the cell type-specific ablation of the cAMP-responsive transcription factor in noradrenergic neurons on locus coeruleus firing and withdrawal behavior after chronic exposure to morphine.

Autorzy: Parlato R, Cruz H, Otto C, Murtra P, Parkitna JR, Martin M, Bura SA, Begus-Nahrmann Y, von Bohlen und Halbach O, von Bohlen und Halbach O, Lüscher C